Optimization of Preparative Technique for Danggui Liuhuang Drop Pills by Regression and Rotation Design

Objective:To optimize the preparative technique of Danggui Liuhuang dripping pills.Methods:Based on the appearance,variation coefficient of weight of pills,time limit of dissolution of the dropping pills,the proper proportion between medicine powder and matrix,the ratio of matrixes,as well as the distance of drops were determined with quadratic regression rotation-orthogonal combination design.Results:The optimum conditions for forming the dropping pills were that the ratio between medicine powder and matrix was 0.5:1,the ratio between PEG4000 and PEG6000 was 0.6:1,the dropping distance was 6.5cm.Conclusion:The preparative technique is convenient,reasonable and feasible.The appearance of the dripping pills is better,the weight variation and the time limit of dissolution of the dropping pills are satisfactory.