Comparison of effect of Phytoestrogens and Hormone Replacement Therapy in the treatment of Perimenopausal Syndrome

Objective To investigate the phytoestrogen treatment of perimenopausal syndrome clinical efficacy and mechanism of action,compare phytoestrogens and hormone replacement therapy for perimenopausal syndrome clinical efficacy. Method 180 patients with perimenopausal syndrome were randomly divided into A and B groups according to treatment order,namely the use of soy isoflavones and hormone replacement therapy for treatment,application Kupper-man symptom score determines the clinical efficacy and treatment of blood testing the indicators before and after the patient serum E2、FSH、LH、P、AKP、TC、TG,were observed before and after treatment control. Results After 4 cycles of therapy,the patient's symptoms improved significantly. Compared with before treatment,Kupperman score decreased significantly( P 0. 01). Compared with before treatment,two groups of patients after treatment,E2 and P were significantly increased,while FSH、LH、AKP、TC、TG were significantly reduced,and the difference was statistically significant( P 0. 05). There was no significant difference efficacy between the two groups( P 0. 05). Conclusion Phytoestrogens can effectively improve the clinical symptoms of perimenopause syndrome,regulate hormone levels in perimenopausal syndrome,promote patient lipid metabolism,and no significant difference in the efficacy of hormone replacement therapy. Phytoestrogens also menopausal and postmenopausal women,cardiovascular protective effect,and can prevent osteoporosis and prevent bone loss.