Effects of stilamin on early postoperative inflammatory small bowel obstruction

Objective To explore the effects of stilamin on early postoperative inflammatory small bowel obstruction.Methods From October 2002 to May 2005,63 patients suffering from early postoperative inflammatory small bowel obstruction were studied prospectively.A double-blind clinical trial involving the administration of somatostatin analogue stilamin for over two days was carried out.(Sixty-three) consecutive patients were randomly divided into experimental group(stilamin therapy group,33 cases) and control group(routine therapy group,30 cases).Clinical symptoms,naso-gastric tube decompression amounts,plain abdominal radiograph and mean hospital stay after onset of obstruction were observed and compared.Results Somatostatin analogue stilamin reduced patient's abdominal distension distinctly,and showedsignificantly smaller and less fluid-air in the small bowel and in the colon at the patient's plain abdominal radiographs.Stilamin had a significant effect on reducing digestive juice loss(525.7±292.5)ml/d versus(895.6±351.4)ml/d,P0.05;shortening patient's mean hospital stay(13.3±8.5)d versus (20.6±11.7)d,P0.05.Conclusion Stilamin can depress digestive juice,relieve intestinal dilatation and promote intestinal peristalsis.Stilamin has a significantly treated effect to the patients with early postoperative inflammatory small bowel obstruction.