Clinical study of somatostatin on intestinal obstruction

Objective To investigate the effects of somatostatin on intestinal obstruction. Methods One hundred and sixty two patients suffering from obstructive ileus were randomly divided into control group and stilamin group. Patients in the control group were treated with routine therapy including gastroenteral decompression,intravenous replacement of fluid and electrolytes,total parenteral nutrition and antibiotics. Patients in the stilamin group received continuous infusion of stilamin (6 mg/d) intravenously plus routine therapy. Results Two to seven days after treatment,the clinical symptoms were significantly improved in stilamin group,the average volume of gastroenteral decompression reduced in stilamin group compared to the control group(277±225)ml/d vs(564±278 )ml/d(P 0.01). The rate of transferring to operation in stilamin group (8.69%) was significantly lower than that in the control group (19.8%)(P 0.05). Conclusions Stilamin combined with routine treatment is an effective method to treat intestinal obstruction such as early postoperative inflammatory small bowel obstruction(EPISBO),adhensive bowel obstruction,pseudo colon obstruction and malignant bowel obstruction.