Effectiveness of Stilamin in Malignant Bowel Obstruction in Patients with Inoperable Gastrointestinal Carcinoma

Objective To investigate the effectiveness of Stilamin in malignant bowel obstruction(MBO) due to inoperable gastrointestinal carcinoma.Methods From Jan.2002 to Jun.2006,62 patients with MBO due to inoperable gastrointestinal carcinoma were randomly divided into two groups: routine therapy group (control group 30 patients) and Stilamin group (32 patients).Stilamin group received routine therapy combined with Stilamin (6mg/d) by 24 hours continuous infusion for three to twelve days.The effectiveness was observed and compared between the two groups.Results 3 days after treatment,the clinical symptoms of abdominal distention and abdominal pain were relieved significantly in Stilamin group compared with the control group (84.4% and 57.6%)(P0.05).The exhaust of anus was more earlier(62.1% and 25.6%)(P0.05).The average volume of gastroenteral decompression reduced more rapidly [(216±158) ml/d and(522±184) ml/d](P0.001).Smaller and less fluid –air in the intestinal and in the colon at the 81.3% of patients plain abdominal radiography were observed in stilamin group.Quality of life,evaluated with Karnofsky score (57±7 and 45±9) (P0.01),was improved significantly.Conclusion The administration of Stilamin combined with routine treatment,is effective in the management of MBO.It can effectively relieve the symptoms of MBO and improve the quality of life in patients.