Relationship between the Extent of Coronary Artery Lesions and BNP

Objective:To explore the relationship between the extent of coronary artery lesion and plama B-type natriuretic peptide(BNP) levels in patients with acute myocardial infarction(AMI) except for heart failure(HF).Method:66 AMI patients without HF were enrolled in the study.24 patients with normal coronary arterography(CAG) served as controls.Plasma BNP levels were measured before CAG.Compare the correlation between BNP and the extent of coronary artery lesions,as well as BNP levels between different infartion site.All statistical analysis was carried on via SPSS17.0 version in personal computer.The data were expressed as(mean±SD) and were analyzed by using t-test.Bi-variance correlation was evaluated by Pearson Correlation Coefficiant.P0.05 indicated statitical significance.Result:The plasma BNP concentrations in patients with AMI were significantly higer than those in controls(P0.001).There was a positive correlation between the BNP levels and coronary artery lesion score(r=0.048).Conclusions:AMI patients without heart failure,the more serious the coronary artery lesions,the higher the plasma BNP concentrations were.BNP may be helpful for the risk stratification and prognosis determination of AMI patients.