Levels of plasma B-type natriuretic peptide and its significance among different clinical phenotypes of coronary heart disease

Objective To explore the relationship between levels of plasma B-type natriuretic peptide(BNP)and clinical phenotypes of coronary heart disease(CHD)and the correlation between BNP concentrations and left ventricular ejection function(LVEF).Methods One hundred and twelve patients with CHD were enrolled in this study including 38 patients with actue myocardial infarction(AMI),50 patients with Vnstable angina pectoris(UAP),and 24 patients with stable angina pectoris(SAP),and 22 persons without CHD as controlgroup.Plasma BNP concentrations were measured and echocardiongrams were detected in all patients to measure LVEF.Correlation between BNP conlentrations and LVEF was also analyzed in every groups.The main outcome measured were heart failure,left romodeliy,mortality and other adverse cardiac events in AMI group.Results Plasma BNP concentrations increased in patients with AMI compared with UAP,SAP and control subjects.The levels of BNP were significantly higher in AMI than that in other three groups(P0.01),and the level of BNP was significantly higher in UAP than that in SAP or control group(P0.01).There were no significant difference in BNP level between SAP and control group(P0.05).Plasma BNP concentrations correlated with LVEF in patients with AMI and UAP.The level of BNP was significantly higher in the patients with heart failure than that with no heart failure in AMI group(P0.05).Conclusion Plasma levels of BNP are associated with clinical phenotypes of coronary heart disease.It could serve as a strong predictor for the subsequent development of poor outcome in patients with AMI.