Change of plasma B-type natriuretic peptide in patients with acute coronary syndrome and its relationship with range of coronary artery pathologic change

Objective To explore the diversity of plasma levels of B-type natriuretic peptide(BNP) in patients with acute coronary syndrome(ACS) and with different degrees of coronary artery lesions.Methods 80 patients with ACS were enrolled in this study,including 45 patients in acute myocardial infarction AMI) group,19 patients in unstable angina pectoris(UAP) group,16 patients in stable angina pectoris(SAP) group,20 persons without CHD as control group.Plasma levels of BNP were detected at 16 to 20 hours after the appearance of symptoms in AMI or on admission in other groups.Comparing the difference of BNP levels among groups.Results Plasma level of BNP were(504.5±182.1) pg/ml,(248.1±171.7) pg/ml,(39.6±22.9) pg/ml and(21.2±16.0) pg/ml in the patients with AMI,UAP,SAP and control respectively.The level of BNP was significantly higher in AMI than in other three groups( P0.01) ,the level of BNP was significantly higher in UAP than in SAP or control(P0.01) ,the level of BNP was higher in SAP than in control(P0.05) .The level of BNP was significantly higher in patients who had complex lesions compared with those who had simple or no lesions(P0.01) .Conclusion Plasma levels of BNP are associated with clinical phenotypes of CHD and elevated levels are significantly associated with more complex lesions.