The expressive level of hepatic fibrosis marker of patients with hepatitis B and its clinical manifestation

Objective To study the relationship between the level of hepatic fibrosis of the patients with hepatitis B and the state of illness and the course of hepatitis.Method The level of hyaluronic acid(HA),Laminin(LN),precollagen type Ⅲ(PⅢC),collagen type Ⅳ(ⅣC) of 135 patients with hepatitis B were detected by radioimmunoassay(RIA) respectively.Results The level of HA、LN、PⅢC、ⅣC in serum of patients was(338.7±122.6),(226.2±43.3),(152.8±33.7) and(132.6±41.1)μg/L respectively.Among them,the level of HA,LN,PⅢC,VIC in serum of patients suffered from acute icteritious hepatitis,chronic hepatitis(slight),chronic hepatitis(moderate),chronic hepatitis(severe),cirrhosis(compensatory phase),cirrhosis(decompensatory phase),hepatic carcinoma,cirrhosis+hepatic carcinoma:HA were(134.2±101.4),(185.1±104.5),(373.5±147.1),(445.5±123.6),(477.3±186.0),(653.7±98.5),(597.5±91.3),(723.6±110.4)μg/L,respectively;LN were(106.7±31.3),(179.5±28.5),(234.6±66.1),(287.3±57.0),(294.8±66.4),(345.6±61.2),(322.1±71.0),(357.8±88.3)μg/L respectively;PⅢC were(103.5±19.2),(108.6±21.4),(145.3±37.3),(194.5±41.7),(188.8±39.5),(247.6±48.0),(251.3±37.3),(286.7±35.8)μg/L,respectively;IVC were(49.6±14.7),(83.4±15.3),(134.5±50.5),(178.7±61.4),(183.2±61.3),(256.8±72.4),(217.7±64.5),(281.1±57.0)μg/L,respectively.Conclusions The sign of hepatic fibrosis of the patients suffered from hepatic carcinoma,cirrhosis,cirrhosis+hepatic carcinoma and chronic hepatitis heavily were obvious.The extent of the patients with acute icteritious hepatitis and slight chronic hepatitis was light.The extent of hepatic fibrosis was closely associated with the state of illness and the course of hepatitis in a certain range.