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2013•China Medicine and PharmacyRequires access

Determination of the content of active pharmaceutical ingredients from Fudosteine by HPLC

Xian Xiao

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Abstract

Objective To establish the method for the content determination of active pharmaceutical ingredients in fudosteine. Methods HPLC was used with C18(250 mm×4.6 mm,5 mm)column,the mobile phase consisted of H 2 O-CH 3 OH(99.5 : 0.5).Wavelength for detection was 220 nm,and the flow rate was 0.8 mL/min. Results The range of calibration curve was y=1 575.2x-1 319,r=0.989 242,the method recovery of fudosteine tablets was 95.89%(RSD=1.7%). Conclusion The method is sensitive, accurate, and can control the quality of fudosteine.

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What this paper is about

Objective To establish the method for the content determination of active pharmaceutical ingredients in fudosteine. Methods HPLC was used with C18(250 mm×4.6 mm,5 mm)column,the mobile phase consisted of H 2 O-CH 3 OH(99.5 : 0.5).Wavelength for detection was 220 nm,and the flow rate was 0.8 mL/min. Results The range of calibration curve was y=1 575.2x-1 319,r=0.989 242,the method recovery of fudosteine tablets was 95.89%(RSD=1.7%). Conclusion The method is sensitive, accurate, and can control the quality of fudosteine.

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Available abstract

Objective To establish the method for the content determination of active pharmaceutical ingredients in fudosteine. Methods HPLC was used with C18(250 mm×4.6 mm,5 mm)column,the mobile phase consisted of H 2 O-CH 3 OH(99.5 : 0.5).Wavelength for detection was 220 nm,and the flow rate was 0.8 mL/min. Results The range of calibration curve was y=1 575.2x-1 319,r=0.989 242,the method recovery of fudosteine tablets was 95.89%(RSD=1.7%). Conclusion The method is sensitive, accurate, and can control the quality of fudosteine.

Key concepts: Medicine, Chromatography, High-performance liquid chromatography, Content determination, Calibration curve, Active ingredient, Pharmacology, Detection limit

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