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2004•Chinese New Drugs JournalRequires access

RP-HPLC determination of fudosteine

Wen Hong-lianga

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Abstract

Objective:To establish a method for determination of fudosteine.Methods:A columnof Shimadzu C_(18) column (150mm×6.0mm,5μm) at room temperature,a mobile phase consisting ofacetonitrile:0.02mol·L~(-1) sodium pentane-sulfonate solution (pH 2)=4∶96 with a flow rate of 1mL·mmin~(-1),and a UV detector at 210nm were adopted.Results:A linear range of 10.1～151.5μg·mL~(-1),amean recovery 99.86% (n=6) with a RSD of 0.48% were obtained.Conclusion:A simple and accu-rate method is established for determination of fudosteine in its bulk pharmaceutical chemical.

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What this paper is about

Objective:To establish a method for determination of fudosteine.Methods:A columnof Shimadzu C_(18) column (150mm×6.0mm,5μm) at room temperature,a mobile phase consisting ofacetonitrile:0.02mol·L~(-1) sodium pentane-sulfonate solution (pH 2)=4∶96 with a flow rate of 1mL·mmin~(-1),and a UV detector at 210nm were adopted.Results:A linear range of 10.1～151.5μg·mL~(-1),amean recovery 99.86% (n=6) with a RSD of 0.48% were obtained.Conclusion:A simple and accu-rate method is established for determination of fudosteine in its bulk pharmaceutical chemical.

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Available abstract

Objective:To establish a method for determination of fudosteine.Methods:A columnof Shimadzu C_(18) column (150mm×6.0mm,5μm) at room temperature,a mobile phase consisting ofacetonitrile:0.02mol·L~(-1) sodium pentane-sulfonate solution (pH 2)=4∶96 with a flow rate of 1mL·mmin~(-1),and a UV detector at 210nm were adopted.Results:A linear range of 10.1～151.5μg·mL~(-1),amean recovery 99.86% (n=6) with a RSD of 0.48% were obtained.Conclusion:A simple and accu-rate method is established for determination of fudosteine in its bulk pharmaceutical chemical.

Key concepts: Chromatography, Chemistry, High-performance liquid chromatography, Sulfonate, Volumetric flow rate, Sodium, Pentane, Recovery rate

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