Microwave radiation for synthesis of isopropyl chloroacetate with PTSA/C as the catalyst

This paper studies the synthesis of isopropyl chloroacetate by using p-toluenesulfonic acid supported on activated carbon as a catalyst under the conditions that the mole ratio between chloroacetic acid and isopropyl alcohol was 1∶ 1.6,cyclohexane was used as a water carrier,and the microwave radiation power was 160 W.The experimental results show that the product of a colorless and transparent liquid is high in purity and recovery rate.The presented method overcomes some shortcomings of the traditional organic reaction such as long reaction time,many secondary reactions,low yield,and low purity,and provides some idea for the synthesis of other chloroacetic acid esters.