2004•Unpublished venueRequires access
Synthesis of Isopropyl Chloroacetate Under Microwave Irradiation
Jianfei Sun
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Abstract
Isopropyl chloroacetate is synthesized from chloroacetic acid and isopropyl alcohol with mordenite as catalysts under the irradiation of microwave. It is investigated that the effects of microwave power(P), irradiation time (T), the amount of catalyst and molar ratio of acid-alcohol on the process. Meanwhile, the optimum operation conditions are obtained by orthogonal experiment and are as follows: microwave power is 480 W, irradiation time is 80 min, the amount of catalyst is 4.0 g5mol~(-1), molar ratio of acid to alcohol is 2.0, the yield of isopropyl chloroacetate is 64.1 %. Comparing with conventional heating method, the heating time under microwave irradiation is less than 1/5 of the former.=