The Effects of Simvastatin on Hemorheology and Endodermis Function of X-syndrome Patient

Objective To study the therapeutic effect of hemorheology and the endodermis function with simvastatin and traditional medicine on patients with X-syndrome,and the serum ET-1、NO、ET/NO.Methods 40 patients with X-syndrome were recruited from October 2006 to October 2007 and randomly divided into two groups (simvastatin group and control group).The control group received routine treatment including β receptor blocker,CCB and long active nitrate.The simvastatin group received simvastatin and the rountine treatment.The clinical condition were performed before and after treatment.Results The frequencies of chest pain in the simvastatin group were lower than that in the control group.The levels of ET-1,plasma viscosity,ET/NO,were significantly decreased in the simvastatin group as compared with the control group after treatment.The levels of NO were significantly increased in the simvastatin group as compared with the control group after treatment.The frequencies of chest pain were positively relative to the level of ET/NO.Conclusion Simvastatin has a treatment effective on patients with X-syndrome and improve endothelium function and hemorheology.