Evaluation of influence of simvastatin on inflammatory factor and safety on ischemic stroke of acute stage

OBJECTIVE To explore the Pharmacological mechanism of simvastatin on the protection of nerves and blood vessel factors,and evaluae the safety of simvastatin on ischemic stroke of acute stage.METHODS 98 patients were divided into three groups randomly:group A 37 cases(elementary medication+ Simvastatin 20 mg·d-1),group B 28 cases(elementary medication+ Simvastatin 40 mg·d-1),and control group 33 cases(elementary medication).Necessary examination were carried out at the second day and the 15th day.RESULTS 1.Inflammatory factor: Compared with control group,CRP was lowered significantly(P0.05) in group A and group B,AAG and HPT was lowered significantly(P0.05)in group B at the 15th day.2.Compared with other two groups,the rising scope of CD62p in group B were lowered significantly at the 15th day(P0.05).3.Compared with control group,CHOL was lowered in A and B 6 groups(Both P0.05),but there was no difference of CHOL among group A and group B.4.The number of platelet in group B were lowered significantly at the 15th day(P0.05) compared with the other two groups.5.Compared with control group,the GPT and the GOT were heighten significantly(P0.05) in group A and group B at the 15th day.CONCLUSION 1.On ischemic stroke of acute stage,simvastatin could decrease the factors of inflammation,the number of platelet,rising scope of CD62p and CHOL in acute cerebral infarction,the effect in group B was greater than that in group A,there was a relation between dosage and curative effect..2.On ischemic stroke of acute stage,simvastatin could decrease CHOL,but there was no difference among group A and group B.3.Simvastatin could cause hepatic function reversible lesion,the functional lesion may be related to individual variation.