2010•Modern Medicine HealthRequires access
MCM5 and Ki-67 expression in breast cancer tissues and its significance
Huang Ze-you
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Abstract
Objective:To investigate the MCM5 and Ki-67 in breast cancer tissues and its significance.Methods:The immunohistochemical SP method was used to detect MCM5 and Ki-67 protein ion in 142 cases of breast cancer tissue,diagnosed by surgery,and 40 cases of normal breast tissue from August 2008 to January 2010 in our hospital.Their expression status was analyzed.Results:Both breast cancer and normal tissues had the expression of MCM5 and Ki-67,the expression of breast cancer tissue was significantly higher than that of the normal tissue (P0.05).MCM5 expression and Ki-67 expression showed positive correlation(r= 0.486 P=0.031).MCM5 expression was related with breast cancer grade,clinical stage,lymph node metastasis (P0.05).Ki-67 was related with clinical stage,lymph node metastasis (P0.05).Conclusion:MCM5 and Ki-67 expression is related with the occurrence and development of breast cancer, which may become the new markers of breast cancer tumor proliferation.