Significance andcorrelation of Ki67 and P16 and Her-2 proteins expression in breast cancer

Objective To study the breast cancer,benign adenomas,peritumoral normal breast tissue Ki67,P16 and Her-2 expression and pathological biological behaviour of relations,united detection Ki67,P16 and Her-2 expression on prognosis assessment,treatment plan formulation with practical significance.Methods Application immunohistochemical SP method to detect 70 cases of breast cancer,15 cases of mammary gland fiber adenoma,15 cases of peritumoral normal breast tissue Ki67,P16 and Her-2 proteins expression.Results The positive rate of Ki67,Her-2 and P16 expression in breast cancer were 68.5%,30.2% and 47.1%,respectively.Ki67,Her-2 expression and P16 was negatively correlated(P0.01).P16 expression were associated with breast cancer staging and lymph node metastasis;Ki67 expression were associated with breast cancer staging and have nothing to do with the lymph node metastasis;Her-2 expression were associated with the lymph node metastasis and have nothing to do with breast cancer staging.Conclusion united detection P16,Ki67 and Her-2 expression treatment and prognosis assessment,follow-up of breast cancer,provides the basis.