Expression of Ki-67 and p53 protein in human breast cancer and its clinical significance

Objective To investigate the expression of Ki-67 and p53 protein in breast cancer and paracarcinoma normal tissue and its clinical significance.Methods The expression of Ki-67 and p53 was examined by S-P immunohistochemistry in 80 samples of breast cancer and 60 samples of paracarcinoma normal tissue.The relationship of Ki-67 and p53 expression with clinicopathological parameters was analyzed.Results The positive expression rate of Ki-67 protein was 63.8% in breast cancer and 8.8% in paracarcinoma normal tissues.The positive expression rate of p53 protein was 68.8% in breast cancer and 11.3% in paracarcinoma normal tissue.The expression of Ki-67 and p53 in breast cancer was not correlated with age,tumor size,ER and PR expression;while correlated with stage,axillary lymph nodes metastasis and C-erbB-2 expression.There was no correlation between the expression rate of Ki-67 and p53 protein.Conclusion Ki-67 and p53 protein may play certain role in carcinogenesis and progress of breast cancer,which may be of value in predicting the biological behavior and metastasis of breast cancer.