Effect of aspirin on cervical cancer cell growth

Objective To explore whether aspirin (acetylsalicylic acid,ASA) inhibits the growth of Caski cells,a cervical cancer cell line,in vitro Methods Caski cells were cultured in the presence of ASA (1～5 mM) for 48 h Cell proliferation was determined by trypan blue exclusion and exceeded 95% Cell cycle distribution was analyzed by flow cytometry Results ASA induced a dose-dependent inhibition of Caski cells in vitro The growth inhibition was 20%～86% at dosages of 1-5 mM ASA induced a shift from S phase to the resting phase (G0/G1) of the cell cycle Conclusions ASA inhibits Caski cell growth in vitro in a dose-dependent manner Apoptosis may be one of the mechanisms involved in the response