Zipraside and risperidone for Schizophrenia: A comparative study

Objective: To investigate the clinical efficacy and side effects of zipraside with risperidone as a control in the treatment of schizophrenia.Methods:A tota1 of 70 cases meeting the criteria of CCM D-3 for schizophrenia were randomly assigned to two group treated with zipraside(zipraside group) or risperidone(risperidone group)for 8 weeks.The positive and negative symptoms scale(PANSS)and treatment emergent symptoms scale(TESS)were used to evaluate the efficacy and adverse effects before treatment and at the end of 2-,4-and 8-week treatment.Results:The therapeutic efficacy in zipraside group was similar to that in risperidone group(P0.05),with no significant difference between the two groups(P0.05).The incidence of adverse effects in zipraside group was lower than that in risperidone group,with no significant difference between the two groups(P0.05),The incidence of extrapyramidal symptoms in risperidone group was significantly higher than that in zipraside group.Conclusion:Zipraside is as effective as risperidone in the treatment of schizophrenia with fewer side effects.