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2007•Journal of North Sichuan Medical CollegeRequires access

A Comparative Study Between Zipraside and Risperidone in the Treatment of Schizophrenia

Yi Quan

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Abstract

Objective To investigate the clinical efficacy and side effects of zipraside in the treatment of schizophrenia.Methods A tota1 of 60 patients met the criteria of CCMD-3 for schizophrenia were randomly assigned to two group treated with zipraside or risperidone for 8 weeks.The Positive and Negative Symptoms Scale(PANSS)and Treatment Emergent Symptoms Scale(TESS)were used to evaluate efficacy and adverse effeets before treatment and at the end of 1St,2nd,4th and 8th week.Results The therapeutic efficacy in zipraside group was similar to that in risperidone group(p 0.05),and there was no significant difference between the two groups(p 0.05).Incidence of adverse effects in zipraside group was lower than that in risperidone group,but the difference was not significant(p0.05),The incidences of extrapyramidal symptoms in risperidone group were significantly higher than those in zipraside group.Conclusion zipraside is as effective as risperidone for treating schizophrenia with 1ower side effects.

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What this paper is about

Objective To investigate the clinical efficacy and side effects of zipraside in the treatment of schizophrenia.Methods A tota1 of 60 patients met the criteria of CCMD-3 for schizophrenia were randomly assigned to two group treated with zipraside or risperidone for 8 weeks.The Positive and Negative Symptoms Scale(PANSS)and Treatment Emergent Symptoms Scale(TESS)were used to evaluate efficacy and adverse effeets before treatment and at the end of 1St,2nd,4th and 8th week.Results The therapeutic efficacy in zipraside group was similar to that in risperidone group(p 0.05),and there was no significant difference between the two groups(p 0.05).Incidence of adverse effects in zipraside group was lower than that in risperidone group,but the difference was not significant(p0.05),The incidences of extrapyramidal symptoms in risperidone group were significantly higher than those in zipraside group.Conclusion zipraside is as effective as risperidone for treating schizophrenia with 1ower side effects.

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Available abstract

Objective To investigate the clinical efficacy and side effects of zipraside in the treatment of schizophrenia.Methods A tota1 of 60 patients met the criteria of CCMD-3 for schizophrenia were randomly assigned to two group treated with zipraside or risperidone for 8 weeks.The Positive and Negative Symptoms Scale(PANSS)and Treatment Emergent Symptoms Scale(TESS)were used to evaluate efficacy and adverse effeets before treatment and at the end of 1St,2nd,4th and 8th week.Results The therapeutic efficacy in zipraside group was similar to that in risperidone group(p 0.05),and there was no significant difference between the two groups(p 0.05).Incidence of adverse effects in zipraside group was lower than that in risperidone group,but the difference was not significant(p0.05),The incidences of extrapyramidal symptoms in risperidone group were significantly higher than those in zipraside group.Conclusion zipraside is as effective as risperidone for treating schizophrenia with 1ower side effects.

Key concepts: Risperidone, Schizophrenia (object-oriented programming), Extrapyramidal symptoms, Medicine, Internal medicine, Adverse effect, Clinical efficacy, Significant difference

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