Study on the expression and relationship of livin and caspase-9,p53 in gastric carcinoma

Objective To study the expression of livin and its relationship with expression of caspase-9 and p53 in gastric carcinoma tissues. Methods Immunohistochemical S-Pmethod was used to detect the expression of livin and caspase-9, p53 proteins in gastric carcinoma tissues and normal gastric mucosas tissues.Results In gastric carcinoma tissues, the positive expressive rate of livin (65.5% vs 3.5%), caspase-9 (20.7% vs 62.1%) and p53 (58.6% vs 5.2%) was respectively significantly higher or lower than that in normal gastric mucosas (all P0.05). The expression of livin was inversely correlated with the histologic differentiation of the tumor, lymph node metastasis and clinical stage (P0.05). A significant negative correlations were observed between the expression of livin and caspase-9 protein in gastric carcinoma tissues (rs=-0.195, P0.05),livin protein expression was positively related to p53 protein expression in gastric carcinoma tissues(rs=0.851,P0. 05).Conclusions Aberrant expression of livin and caspase-9 may be a new target for diagnosis, porgnosis assessment and gene treatment of gastric carcinoma. The aberrant expression of livin and inhibiting carcinoma gene p53 may play facilitative roles in process of carcinogenesis of gastric carcinoma.