Study on Expression of Livin and its Relationship with Caspase 3 in Gastric Carcinoma

Objective:To investigate the expression of Livin in gastric carcinoma and to determine its relationship with Caspase 3.Methods:To detect expressions of Livin protein and Caspase 3 protein in gastric carcinoma(n = 60),benign dis-ease(n = 10) and normal tissues(n = 10) by immunohistochemistry(SP method).Results:The positive rates of Livin protein ex-pression were 0,20% and 66.7% in the gastric carcinoma,benign disease and normal tissues respectively(P 0.01 or P 0.05).The positive rates of Caspase 3 protein were 70%,50%,18.3% in the three groups respectively(P 0.01 or P 0.05).There was a correlation between expression of Livin and the infiltrative depth of gastric carcinoma tissues(P 0.05),but there were no correlation to gender,age,pathological types and lymphoid node metabasis(P 0.05).The expression of Caspase 3 was negatively correlated with the expression of Livin(P 0.01).Conclusion:High incidence of positive expression of Livin in gastric carcinoma may provide valuable diagnostic and prognostic marker.