Clinical observation of large dose naloxone in acute carbon monoxide poisoning

Objective:To study the safety and curative effect of large dose naloxone in patients with acute carbon monoxide(CO) poisoning in pre-hospital.Methods:145 patients with acute CO poisoning were involved in a randomized controlled trial. 69 patients received traditional medication as the control group, 76 patients in the observation group received the scheme that the large dose naloxone was used in pre-hospital on the base of the control group, first,intravenous 2mg naloxone, followed with 12mg naloxone in 5% glucose saline 500ml intravenous last for 24 hours with a micro-pump. The Glascow coma scale before treatment,4 hours, 8 hours, 24 hours, 48 hours and 72 hours after administration, the average analeptic time during the period of having been treated, and the rate of the delayed encephalopathy after carbon monoxide poisoning (DEACMP) at two months after poisoning in the two groups were observed.Results:The Glascow coma scale, the average analeptic time, and the rate of the DEACMP demonstrated notable differnce between the two groups, and no side-effects.Conclusion: The large dose naloxone used in this manner is better than normal dose in safety and curative effect for saving acute CO poisoning.