Relation of Total Serum Bile Acid and Indexes of Liver Fibrosis to the Child-Pugh Grading

Objective:To study the possible relationship of the level of total serum bile acid(TBA) and liver fibrosis indexes including serum IV collagen(IV-C),hyaluronic acid(HA),and liver fibrosis scoring by ultrasound to different Child-Pugh grades in patients with HBV-related cirrhosis.Methods:Patients with HBV-related cirrhosis were divided into A,B,and C groups according to the Child-Pugh grades.TBA,HA,and IV-C were tested and liver fibrosis scores were measured by ultrasound.Results:n the A,B,and C groups,TBA was(9.00 4.40),(21.43±14.18),and(46.27±29.78) μmol/L,HA was(313.20±104.59),(366.37±158.46),and(527.00±157.29)ng/ml,IV-C was(238.05±36.68),(355.63±27.43),and(493.97±109.58)ng/ml,and liver fibrosis score was(10.70±3.76),(13.10±3.50),and(14.50±3.12),respectively.The levels of these indexes were elevated as the increase of the severity of liver cirrhosis and the difference in each index was statistically significant within each group(P0.05).The indexes themselves were interrelated(P0.05).Conclusion:TBA,HA,IV-C,and ultrasound scores were correlated and they are useful markers to diagnose the severity of HBV-related liver cirrhosis.