Correlational research of serum ferritin and hyaluronic acid in patients with cirrhosis

Objective To investigate the relationship between serum ferritin(SF) and hyaluronic acid(HA) in patients with cirrhosis.Methods Data of 70 patients with cirrhosis were collected.The average age was 46.93±13.34 years and there were 16 females and 54 males.All the cases were divided into three groups: Child pugh A,B,and C according to Child pugh ranking.Serum SF and HA levels were determined by chemiluminescent immunoassay.Then multiple comparison between groups and the relationship between serum HA levels and HBV DNA levels was analyzed.Results 1.The level of SF increased obviously in the cases with cirrhosis.The serum SF increased gradually according to the progress of the degree of clinical liver cirrhosis and the highest level of HA was observed in the patients with Child pugh C.The significant difference of the HA levels in the patients between grade A and B,B and C,and C and A was observed(P0.01).2.The level of HA increased obviously in the cases with cirrhosis.The highest level of SF was observed in the patients with Child pugh C.The significant difference of the HA levels in the patients between grade A and B,B and C,and C and A was observed(P0.01).3.SF and HA are significantly correlated in the patients in different grade of cirrhosis(r=0.828,P0.001).Conclusions SF and HA are significantly correlated in the patients in different grade of cirrhosis and both of them are important to reflect the level of cirrhosis.They are both sensitive markers of hepatic fibrosis in cirrhosis.