To Explored The Judgeing Value the Severe Of Hepatocirrhosis of Serum Liver Fibrosis Index

Objective To investigate the clinical diagnosis value of serum hyaluronic acid(HA), aminoterminal propeptide of type Ⅲ procollagen(P ⅢP), laminin(LN) and Ⅳ collagen (Ⅳ-C) with the severity of liver fibrosis and inflammation in cirrhosis.Methods A total of 84 patients with HBV-related cirrhosis were enrolled. All patients' serum fibrosis markers including hyaluronic acid (HA), aminoterminal propeptide of type Ⅲ procollagen(PⅢP), laminin(LN) and Ⅳ collagen (Ⅳ-C)were detected by linked immunosorbentassay (ELISA) method. The patient were divided into three group according their child-pugh grade. and compared with each other. Results Compared with control group, there were significant difference of HA、P ⅢP、LN、 Ⅳ-C in each child-pugh A,B,C group by SNK method.( P0.05). Compared with hyaluronic acid of each group, there were on different between child-pugh A group and B group, but there were significant difference between child-pugh C group and A group( P0.05). Compared with Ⅳ collagen of each other , there were significant difference by child-pugh A group, B group and C group. Ⅳ collagen were correlated negatively with cholineseterase(P0.05). Hyaluronic acid(HA) and Ⅳ collagen (Ⅳ-C) were correlated positively with pro- thrombin time.Conclusion Hyaluronic acid(HA) and Ⅳ collagen (Ⅳ-C)were correlated with severe of cirrhosis and maybe one usefully independent predictor of prognosis.