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2010•Zhongguo tangniaobing zazhiRequires access

Glycosylated hemoglobin does not apply to the screening and diagnosing of gestational diabetes mellitus

Min Nie

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Abstract

Objective To investigate the value of HbA_1c in the screening and diagnosing of gestational diabetes mellitus ( GDM).Methods 3h OGTT and HbA_1c assay were performed in 1815 pregnant women with positive results of 50g glucose challenge test(GCT).HbA_1c distributions in subjects with normal glucose tolerance ( NGT),gestational impared glucose tolerance (GIGT) and GDM were compared,and area under curve(AUC) of receiver operating characteristic(ROC) curve was calculated. Results There was considerable overlap in HbA_1c distributions among three groups.AUC of ROC curve was 0.658,95% confidence interval(CI) was 0.626～0.690.Conclusions HbA_1c does not apply to the screening and diagnosing of gestational diabetes in early stage.

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What this paper is about

Objective To investigate the value of HbA_1c in the screening and diagnosing of gestational diabetes mellitus ( GDM).Methods 3h OGTT and HbA_1c assay were performed in 1815 pregnant women with positive results of 50g glucose challenge test(GCT).HbA_1c distributions in subjects with normal glucose tolerance ( NGT),gestational impared glucose tolerance (GIGT) and GDM were compared,and area under curve(AUC) of receiver operating characteristic(ROC) curve was calculated. Results There was considerable overlap in HbA_1c distributions among three groups.AUC of ROC curve was 0.658,95% confidence interval(CI) was 0.626～0.690.Conclusions HbA_1c does not apply to the screening and diagnosing of gestational diabetes in early stage.

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Available abstract

Objective To investigate the value of HbA_1c in the screening and diagnosing of gestational diabetes mellitus ( GDM).Methods 3h OGTT and HbA_1c assay were performed in 1815 pregnant women with positive results of 50g glucose challenge test(GCT).HbA_1c distributions in subjects with normal glucose tolerance ( NGT),gestational impared glucose tolerance (GIGT) and GDM were compared,and area under curve(AUC) of receiver operating characteristic(ROC) curve was calculated. Results There was considerable overlap in HbA_1c distributions among three groups.AUC of ROC curve was 0.658,95% confidence interval(CI) was 0.626～0.690.Conclusions HbA_1c does not apply to the screening and diagnosing of gestational diabetes in early stage.

Key concepts: Gestational diabetes, Medicine, Receiver operating characteristic, Diabetes mellitus, Confidence interval, Area under the curve, Internal medicine, Hemoglobin

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