Clinical Significance of Glycosylated Hemoglobin Test in Gestational Diabetes Mellitus

Objective To investigate the clinical significance of determination of glycosylated hemoglobin(HbA1c) in patients with gestational diabetes mellitus(GDM).Methods The levels of fasting plasma glucose(FPG) and glucose challenge test(GCT) with 50g glucose in 309 pregnant women with normal glucose tolerance(NGT),101 pregnant women with gestational impaired glucose tolerance(GIGT) and 279 pregnant women with gestational diabetes mellitus(GDM) were determined.75g glucose tolerance test(OGTT) was done to those whose abnormal GCT did not meet the diagnostic criteria for GDM.Meanwhile,the levels of HbA1c of all subjects were assessed.And all subjects were divided into some groups according to their levels of HbA1c to investigate the relationship between the complication and the level of HbA1c.Results The results of HbA1c,FPG,and GCT with 50g glucose of GDM group were significantly higher than those in NGT group(P0.01).The positive rate of HbA1c in GDM was 37.3%.It was not sensitive if diagnosed only by this sign,but diagnosis by both FPG and this sign could solve this problem.Moreover,the incidence of complication was increasing with the rise of HbA1c titer in the study groups(P0.01).Conclusions It is of great value to determination of HbA1c in screening,diagnosing and assessing the prognoses of gestational diabetes mellitus.