Application of glycosylated hemoglobin screening test in the determination of gestational diabetes

Objective To explore the feasibility and clinical significance of glycosylated hemoglobin(HbA1c) screening test in the determination of gestational diabetes(GDM).Methods The results of oral glucose 50 g challenge test(GCT) and HbA1c levels were analyzed in 64 normal pregnancy cases,23 gestational impaired glucose tolerance cases and 48 gestational diabetes cases.OGTT test was the gold standard in diagnosing GDM.ROC curve was used to evaluate the value of the screening test of GDM by GCT and HbA1c.Results The value of GCT and HbA1c in GDM group were higher than those in the other two groups respectively.The sensitivity and specificity of GCT were 66.7%~70.8% and 62.1%~65.5% respectively when the cut point value of GCT was 7.8mmol/L,while those of HbA1c were 72.9%~75.0% and 85.1%~88.5% respectively when the cut point value of HbA1c was 6.0% by ROC curve analysis.Conclusion HbA1c can be used as a conception of gestational diabetes diagnosis,but further studies are needed to figure out the cut point.