Effect of Modified Didang Decoction on t-PA,PAI-1 and PAl-1 Gene Express in Fat in InsuIin Resistance Rats

Objective:To explore the effect of modified Didang decoction on t-PA,PAI-1 and PAI-1 gene expression in fat in insulin resistance rats.Methods:The insulin resistance rats were randomly divided into the control group,the model control group,the high,medium and low dosage of modified Didang decoction groups and Wendiya group.Chromogenic Assay kit and Reverse transcriptase polymerase chain reaction were used to observe the effect of modified Didang decoction on the t-PA,PAI-1 and PAI-1 mRNA of fat in rats.Results:The t-PA was significantly higher and PAI-1 and PAI-l gene expression level significantly lower in the high and medium dose of modified Didang decoction(P0.05 or P0.01).Conclusion:Through up-regulation on t-PA and down-regulation on PAI-1 and PAI-1 gene expression is possibly one of the mechanisms of modified Didang decoction in treating insulin resistance.