Study on the Expression of LMP1,CyclinD1 and Bcl-2 in Nasopharyngeal Carcinoma and Its Clinical Significance

Objective To investigate LMP1,CyclinD1 and Bcl-2 expression in nasopharyngeal carcinoma(NPC) and its clinical significance,and analyze their relation. Methods LMP1,CyclinD1 and Bcl-2 expression was assayed respectively in 60 NPC tissues by immunohistochemical method. Results ⑴The positive expression rates of LMP1,CyclinD1 and Bcl-2 in NPC were 65%(39/60), 60%(36/60)and 65%(39/60) respetively; ⑵The mean survival period, the five-year survival rate and median survival period in the NPC patients with LMP1, cyclinD1 and Bcl-2 positive expression were significantly shorter than those in the NPC patients with LMP1, cyclinD1 and Bcl-2 negative expression (P0 05); ⑶the co-expression rate of CyclinD1 and Bcl-2 was 68 33%(41/60) with significant correlation (γ=0 399,P0 01), and there was not significant expression relationship between LMP1 and CyclinD1, and between LMP1 and Bcl-2; ⑷There was significant difference in LMP1, CyclinD1 expression among stages Ⅱ, Ⅲ and Ⅳ of NPC(P0 05). Conclusion LMP1 expression may be an independent prognostic marker in NPC, and the expression of CyclinD1 and Bcl-2 may be helpful in evaluating NPC prognosis.