Expression and Correlation of T-cadherin and LMP-1 in Nasopharyngeal Carcinoma

Objective To research the expression of T-cadherin and LMP-1 in nasopharyngeal carcinoma(NPC),investigate the correlation between them and the relationship between abnormal expression of T-cadherin gene and the clinicopathological characteristics of nasopharyngeal carcinoma.Methods Expression of T-cadherin and LMP-1 in 50 NPCs and 20 nasopharyngitis tissues was detected by SP immunohistochemical method.The relationship between T-cadherin differential expression and clinical pathological factors in nasopharyngeal carcinoma was analyzed.Results In NPC and nasopharyngitis tissue,the positive expression rates of T-cadherin were 40% and 100%(P0.01),and those of LMP-1 were 64% and 20%(P0.01)respectively.Spearman correlation analysis showed that the expression of T-cadherin and LMP-1 was negatively correlated in NPC.The expression of T-cadherin in NPC was correlated with TNM stage and lymph node metastasis.T-cadherin expression had no significant correlation with age,gender and tumor diameter.Conclusion T-cadherin expression in NPC is significantly lower and negatively correlated with LMP-1 expression,suggesting the abnormal expression of T-cadherin and LMP-1in NPC may play an important role in the initiation,progression and metastasis of NPC.