Study on the expression of HSP70,Bcl-2 and PCNA in nasopharyngeal carcinoma and clinical significance

Objective To investigate heat shock protein 70 (HSP70), Bcl-2 and proliferation cell nuclear antigen (PCNA) expression in nasopharyngeal carcinoma (NPC) and clinical significance, and analysize their relations. Method HSP70, Bcl-2 and PCNA expression were andlysed respectively in 60 nasopharyngeal carcinoma tissue by immunohistochemical method. Results ① the positive expression rates of HSP70, Bcl-2 vs PCNA in NPC were 70% (42/60)?65% (39/60) and 86.7% (52/60) respectively. ② the mean survival period, the five-year-survival rate and median survival period in Bcl-2 and PCNA positive expression group were shorter than Bcl-2 and PCNA negative expression group (P 0.05); there is also significant difference among different stages of NPC as to the survival condition; but no significant survival difference showed between HSP70 positive group and negative group. ③ the coincidence rate of HSP70 and Bcl-2 expression was 75% (45/60) and significant correlation showed between HSP70 and Bcl-2 (P 0.05), no significant correlation existed between HSP70 and PCNA, PCNA and Bcl-2. ④ There is significant difference of HSP70?PCNA expression in stage Ⅱ?Ⅲ?Ⅳ of NPC (P 0.05). Conclusion HSP70 expression could reflect clinical stage of NPC, but was not significant in survival of NPC patients; Bcl-2?PCNA expression may be a useful prognosis marker in NPC.