ScholarLens Back to search
2010•Journal of OncologyRequires access

The Expression of p16 and CyclinD1 in Nasopharyngeal Carcinoma and its Clinical Significance

Cheng Sen-qing

Open publisher page 2 citations

Abstract

[Purpose] To investigate the gene loss and expression of p16 and CyclinD1 in nasopharyngeal carcinoma(NPC),their correlation and clinical significance. [Methods] Gene loss of p16 in 151 specimens with NPC was detected by polymerase chain reaction(PCR). The expression of p16 and CyclinD1 protein in NPC and normal nasopharyngeal tissue were detected by SP immunohistochemistry. [Results] Loss rate of p16 gene exon 2 in NPC was 35.76%(54/151). Low expression of p16 in NPC(P0.0001) didn't correlate to gender,age and stage(P0.05). High expression of CyclinD1(P0.0001) didn't correlate to gender,age and stage (P0.05). [Conclusion] The loss of p16 gene exon 2 is found in NPC. There is a negative correlation between low expression of p16 and high expression of CyclinD1 in NPC(P0.0001).

About this research paper

What this paper is about

[Purpose] To investigate the gene loss and expression of p16 and CyclinD1 in nasopharyngeal carcinoma(NPC),their correlation and clinical significance. [Methods] Gene loss of p16 in 151 specimens with NPC was detected by polymerase chain reaction(PCR). The expression of p16 and CyclinD1 protein in NPC and normal nasopharyngeal tissue were detected by SP immunohistochemistry. [Results] Loss rate of p16 gene exon 2 in NPC was 35.76%(54/151). Low expression of p16 in NPC(P0.0001) didn't correlate to gender,age and stage(P0.05). High expression of CyclinD1(P0.0001) didn't correlate to gender,age and stage (P0.05). [Conclusion] The loss of p16 gene exon 2 is found in NPC. There is a negative correlation between low expression of p16 and high expression of CyclinD1 in NPC(P0.0001).

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

[Purpose] To investigate the gene loss and expression of p16 and CyclinD1 in nasopharyngeal carcinoma(NPC),their correlation and clinical significance. [Methods] Gene loss of p16 in 151 specimens with NPC was detected by polymerase chain reaction(PCR). The expression of p16 and CyclinD1 protein in NPC and normal nasopharyngeal tissue were detected by SP immunohistochemistry. [Results] Loss rate of p16 gene exon 2 in NPC was 35.76%(54/151). Low expression of p16 in NPC(P0.0001) didn't correlate to gender,age and stage(P0.05). High expression of CyclinD1(P0.0001) didn't correlate to gender,age and stage (P0.05). [Conclusion] The loss of p16 gene exon 2 is found in NPC. There is a negative correlation between low expression of p16 and high expression of CyclinD1 in NPC(P0.0001).

Key concepts: Nasopharyngeal carcinoma, Immunohistochemistry, Exon, Medicine, Clinical significance, Stage (stratigraphy), Gene, Gene expression

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The Expression of p16 and CyclinD1 in Nasopharyngeal Carcinoma and its Clinical Significance — Research Paper | ScholarLens