The efficacy and safety of sertraline combined with quetiapine in treatment of obsessive-compulsive disorder

Objective To discuss the efficacy and safety of sertraline combined with quetiapine in treatment of obsessive-compulsive disorder. Methods Selected 100 patients with OCD from Dec 2012 to Jun 2013 admitted to our hospital were divided into treatment group and control group according to the assigned randomly, each group with 50 cases. The control group was treated with sertraline, and the treatment group was treated with sertraline combined with quetiapine. After treatment of 8 weeks, the clinical efficacy between two groups was compared. Results After treatment, the Yale Brown Obsessive Compulsive Scale, the Brief Psychiatric Rating Scale and Hamilton Anxiety Scale score of two groups were significantly lower than those before treatment, and the patients in the treatment group were decreased more than control group, which was statistically significant(P 0.05). Conclusion Sertraline combined with quetiapine in treatment of obsessive-compulsive disorder shows better efficacy than sertraline alone, worthy of clinical promotion and application.