A random and comparative study of sertraline combining with quetiapine in the treatment of refractory obsessive-compulsive disorder

Objective:To investigate the efficacy and safety of sertraline combining with quetiapine in the treatment of refractory obsessive-compulsive disorder(OCD).Method:A total of 64 patients who met the criteria for refractory OCD were randomly assigned to the two groups.One group was treated with sertraline combining with quetiapine and the other one with sertraline only for 8 weeks.The efficacy was measured with Yale-Brown obsessive compulsive scale(Y-BOCS),Hamilton depression scale(HAMD).The side effects were assessed by treatment emergent symptoms scale(TESS).Results:One patient in sertraline group had falled off and was out of statistical analysis.At endpoint the significant improvement rate of the combining group is 56.3% and that of the sertraline group is 25.8%(χ2 = 6.021,P=0.014).The YBOCS and HAMA score decreased more in the combining group than the sertraline group(Y-BOCS:t=2.561,P=0.013;HAMA:t=3.059,P=0.003).There were no significant differences in the TESS score decrese between the two groups(P0.05).Conclusion:The addition of quetiapine to sertraline therapy has been found to be effective and well-tolerated approach in patients with refractory OCD.