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486 samples analysis of peripheral blood chromosome from reproduction abnormality patients

Luo Chu

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Abstract

Objective To investigate the relationship between sterility,spontaneous abortion and abnormal chromosome karyotypes,and that would be help for clinical diagnosis for hereditary disease.Methods To collect peripheral blood samples from 486 reproduction abnormality patients.Chromosome specimens were made using routine culture of peripheral blood lymphocytes.The G-band technique was used in the cytogenetical analysis.Results Forty-one of 486 cases of patients(8.4%) were abnormal chromosome karyotypes.Among the 41 cases involving abnormal karyotypes,there were 20 spontaneous abortion(6.9%),10 sterility(10.6%).Conclusion Chromosome abnormalities are the important factors resulting in female/male infertilities.Chromosome investigation should be tried to do for reproduction abnormality patients.

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What this paper is about

Objective To investigate the relationship between sterility,spontaneous abortion and abnormal chromosome karyotypes,and that would be help for clinical diagnosis for hereditary disease.Methods To collect peripheral blood samples from 486 reproduction abnormality patients.Chromosome specimens were made using routine culture of peripheral blood lymphocytes.The G-band technique was used in the cytogenetical analysis.Results Forty-one of 486 cases of patients(8.4%) were abnormal chromosome karyotypes.Among the 41 cases involving abnormal karyotypes,there were 20 spontaneous abortion(6.9%),10 sterility(10.6%).Conclusion Chromosome abnormalities are the important factors resulting in female/male infertilities.Chromosome investigation should be tried to do for reproduction abnormality patients.

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Available abstract

Objective To investigate the relationship between sterility,spontaneous abortion and abnormal chromosome karyotypes,and that would be help for clinical diagnosis for hereditary disease.Methods To collect peripheral blood samples from 486 reproduction abnormality patients.Chromosome specimens were made using routine culture of peripheral blood lymphocytes.The G-band technique was used in the cytogenetical analysis.Results Forty-one of 486 cases of patients(8.4%) were abnormal chromosome karyotypes.Among the 41 cases involving abnormal karyotypes,there were 20 spontaneous abortion(6.9%),10 sterility(10.6%).Conclusion Chromosome abnormalities are the important factors resulting in female/male infertilities.Chromosome investigation should be tried to do for reproduction abnormality patients.

Key concepts: Sterility, Karyotype, Abnormality, Chromosome, Peripheral blood, Abortion, Chromosome abnormality, Chromosomal Abnormality

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