Cytogenetic analysis on 319 cases of fertility abnormality patients in Xinjiang area

Objective To investigate the relationship between chromosome abnormality and fertility abnormality.Methods The peripheral lymphocytes of 319 cases of fertility abnormality patients were cultured and the abnormal karyotypes were analyzed by chromosome G banding technique.Results There were 72 cases of abnormal karyotypes with the aberration rate of 22.57 ％.Among the abnormal cases,2 karyotypes harbored abnormal number of sex chromosome (2.7 8 ％),1 case carried abnormal structure of sex chromosome (1.39％),10 cases were abnormal karyotypes of euchromosome structure (13.89％),and 59 cases were abnormal karyotypes of chromosome polymorphism (8 1.96％).Conclusion Chromosome aberration is one of the important reasons which causes of fertility abnormality,and there is a correlation between the chromosome polymorphism and fertility abnormality,so it is necessary to perform chromosome analysis for the patients of fertility abnormality. Key words: Fertility abnormality ;  Chromosome ;  Abnormal karyotype