922 samples analysis of chromosome from reproduction abnormality patients.

Objective: To investigate the relationship between sterility,spontaneous abortion and abnormal chromosome karyotypes,and that would be help for clinical diagnose for hereditary disease.Methods: 922 reproduction abnormality patients′ were performed by peripheral blood lymphocytes cultivating to make chromosome G-banding.Results: 66 of 922 cases of patients(7.16%) were abnormal chromosome karyotypes.Among 21 cases are chromosome translocations,21 cases are inversion chromosomes,18 cases are Klinefelter′s syndromes,1 case is Turner′s syndromes and deletion X-chromosome,1 case is Y-chromosome deletion,1 case is ring 21-chromosome,1 case is marker chromosome,63 cases are polymorphism of Y-chromosome accounting for 13.35%.Conclusion: Chromosome abnormalities are the important factors resulting in female/male infertilities.we advocate that should try to do chromosome investigation for reproduction abnormality patients.