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2005•Experimental PathologyRequires access

Expression and significance of MMP-2 and TIMP-2 in human colorectal carcinoma and its metastasis

Xiang Du

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Abstract

Purpose To understand the relationship between the expression of MMP-2,TIMP-2 and the clinical significance in human colorectal carcinoma.Methods Immunohistological staining was used to detect the expression of MMP-2 and TIMP-2 in 104 cases of human colorectal carcinoma and their metastatic lesions.Results The expression rates of MMP-2 were 53.8% and 72.1% in colorectal carcinomas and metastatic lesions respectively;expression rates of TIMP-2 were 66.3% and 35.6%,respectively;the expression of MMP-2 and TIMP-2 was negatively correlated between primary and metastatic lesions of colorectal carcinoma.Conclusions The expression of MMP-2 and TIMP-2 is closely correlated to human colorectal carcinoma metastasis,and might be served as a useful parameter for determining tumor biological behavior.

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Purpose To understand the relationship between the expression of MMP-2,TIMP-2 and the clinical significance in human colorectal carcinoma.Methods Immunohistological staining was used to detect the expression of MMP-2 and TIMP-2 in 104 cases of human colorectal carcinoma and their metastatic lesions.Results The expression rates of MMP-2 were 53.8% and 72.1% in colorectal carcinomas and metastatic lesions respectively;expression rates of TIMP-2 were 66.3% and 35.6%,respectively;the expression of MMP-2 and TIMP-2 was negatively correlated between primary and metastatic lesions of colorectal carcinoma.Conclusions The expression of MMP-2 and TIMP-2 is closely correlated to human colorectal carcinoma metastasis,and might be served as a useful parameter for determining tumor biological behavior.

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Available abstract

Purpose To understand the relationship between the expression of MMP-2,TIMP-2 and the clinical significance in human colorectal carcinoma.Methods Immunohistological staining was used to detect the expression of MMP-2 and TIMP-2 in 104 cases of human colorectal carcinoma and their metastatic lesions.Results The expression rates of MMP-2 were 53.8% and 72.1% in colorectal carcinomas and metastatic lesions respectively;expression rates of TIMP-2 were 66.3% and 35.6%,respectively;the expression of MMP-2 and TIMP-2 was negatively correlated between primary and metastatic lesions of colorectal carcinoma.Conclusions The expression of MMP-2 and TIMP-2 is closely correlated to human colorectal carcinoma metastasis,and might be served as a useful parameter for determining tumor biological behavior.

Key concepts: Colorectal cancer, Metastasis, Matrix metalloproteinase, Medicine, Clinical significance, Carcinoma, Immunohistochemistry, Oncology

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Expression and significance of MMP-2 and TIMP-2 in human colorectal carcinoma and its metastasis — Research Paper | ScholarLens