Olanzapine(note-min) and clozapine in the treatment of refractory schizophrenia:A contrast study

Objective To investigate the efficacy and safety of olanzapine(note-min) in the treatment of refractory schizophrenia.Methods The 65 patients with refractory schizophrenia were randomly divided into two groups(study group:34 patients,the control group:31 cases);and respectively subjected to olanzapine(note-min) in study group,and clozapine treatment in coutrol group;treatment for 12 weeks;Positive Symptoms and Negative Symptoms Scale(PANSS) assessment of efficacy,adverse reactions with the scale(TESS) assessment of adverse reactions were made.Results Olanzapine(note-min) in the treatment response rate was 47.1%,clozapine 45.2%,overall efficacy difference between the two groups was not statistically significant(P0.05);olanzapine(note-min) in adverse response was low and mild.Conclusion The therapeutic effect of olanzapine(note-min) in the treatment of refractory schizophrenia is considerable as clozapine,and of high security.