Effect of olanzapine combined with clozapine in the treatment of negative symptoms in male treatment-resistant schizophrenic patients.

Objective To explore the efficacy and side effects of olanzapine combined with clozapine for treating negative symptoms of male patients with treatment-resistant schizophrenia.Methods A total of 43 male treatment-resistant schizophrenic inpatients with negative symptoms treated with clozapine were assigned to receiving olanzapine 5-20mg/d for 8 weeks,at the same time reducing clozapine to a maintenance dose in 2 weeks.The Positive and Negative Symptom Scale(PANSS) and Treatment Emergent Symptoms Scale(TESS) were used to measure therapeutic efficacy and side effects before the treatment and at 2nd、4th and 8th weekends after the treatment.Results After treatment,the scores of PANSS and TESS in patients significantly dereased.Conclusion Olanzapine combined with clozapine in male inpatients with treatment-resistant schizophrenia can improve negative symptoms with fewer side effects.