A COMPARATIVE STUDY OF FLUVOXAMINE AND SERTRALINE IN THE TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER

Objective To discuss the clinical efficacy and the adverse reactions of fluvoxamine and sertraline in the treatment of obsessive-compulsive disorder(OCD).Methods A total of 58 patients who met the CCMD-3 criteria for OCD were randomly assigned to two groups.One group was treated with fluvoxamine and the other with sertraline for 10 weeks.The efficacy was measured with Yale-Brown Obsessive Compulsive Scale(Y-BOCS),Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA).The adverse reactions were assessed by Treatment Emergent Symptoms Scale(TESS).Results The improvement rate of fluvoxamine was 85.71%,and the improvement rate of sertraline was 82.14%.There were no significant differences between two groups.According to the reducing scores of Y-BOCS,HAMD and HAMA,there were significant differences in the two groups from the fourth weekend.The adverse reaction of fluvoxamine was similar to that of sertraline.Conclusion Fluvoxamine and sertraline are effective antidepressants with few adverse reactions and patients can have good drug tolerance.