Observation on Oxaliplatin Combined with Fluorouracil and Calcium Folinate in the Treatment of 40 Cases of Advanced Colorectal Cancer

Objective To study the response and toxicity of the regimen of oxaliplatin combined with fluorouracil and calcium folinate in the treatment of advanced colorectal cancer.Methods:The regimen was oxaliplatin 130 mg/m 2 hours iv drip on the 1st day,calcium folinate 200 mg/m 2 iv drip 2 hours on days the 1st to 5 th ,followed by fluorouracil 300 mg/m 2(≤500 mg/d) iv drip 4 hours on the 1st to the 5 th ,and 21 days as one cycle.Results:The total response rate was 30%,the main toxicity was bone marrow suppression and neuro sensory toxicity.Leukopenia was observed in 45% of the patients,neuro sensory toxicity was observed in 80%.There was no toxicity and side effect of grade Ⅳ in these patients.Conclusions The regimen of oxaliplatin combined with fluorouracil and calcium folinate is effective and tolerable in advanced colorectal cancer therapy.