2006•Hecheng huaxueRequires access

Synthesis of Artificial Antigens of 2,4,6-Trichlorophenol

Huisheng Zhuang

Abstract

2,4,6-Trichlorophenoxiacetic acid(hapten) was synthesized from 2,4,6-trichlorophenol(TCP) and chloroactic acid.The hapten was conjugated to bovine serum albumin(BSA) by the modified active ester method to form artificial immune antigen(TCP-BSA).And the coating antigen(TCP-OVA) was synthesized by conjugated hapten to ovalbumin(OVA) with the mixed-anhydride method.

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Key concepts: Chemistry, Hapten, Ovalbumin, Bovine serum albumin, Conjugated system, Antigen, Chromatography, Combinatorial chemistry