The Value of Treating Diabetic Nephropathy with Benazepril and Valsartan

Objective: To observe the clinical effective of combination of benazepril and valsartan on treating diabetic nephropathy.Method: 46 patients with diabetic nephropathy in IV phase were randomly divided into three groups.Observation group contained the combination of benazepril and valsartan Other two groups served as control groups benazepril group and valsartan group.The treatment lasted for 12 weeks,24 hours quantitative test for urinary protein,renal function and serum potassium.Baseline treatment included insulin and oral hypoglycemic agents.Supplement with hypotensors such as calcium antagonism if necessary,blood sugar and blood pressure were maintained in normal range.Result: There was a decrease of urinary protein after 12 weeks of treatment in all groups.More significant in observation group compared to that of control groups(P0.05).No hyperkalemia and renal failure were observed.Conclusion: Combination of benazepril and valsartan on treating diabetic nephropathy can decrease urinary protein,then enhanced clinical effectives.