Effect of Benazepril with Valsartan on Idiopathic Membranous Nephropathy in Early Stage

Objective To explore the efficiency of Benazepril combined with valsartan in treatment of idiopathic membranous nephropathy(IMN) in the early stage.Methods Sixty two cases of IMN were randomly divided into control group,valsartan group,Benazepril group and Benazepril with valsartan group by a prospective randomized controlled trial.The patients in all groups received a low-protein diet and lipid-lowering therapy.The valsartan group was treated with valsartan 80 mg/d and should be increased to 160 mg/d if there was no hypotension and other side effects;the Benazepril group as treated with Benazepril 10 mg/d and should be increased to 20 mg/d if there was no hypotension and other side effects;the combination group received Benazepril 10-20 mg/d every day based on the valsartan group.The courses of all groups were 8 weeks.Results The 24-hour urinary albumin excretion has decreased as compared to the levels before treatment except the control group(P0.01),and the difference was more significant between the combination group and other groups(P0.05).Conclusion Benazepril with valsartan can rapidly decrease the 24-hour urinary albumin excretion and promote the level of serum albumin in early idiopathic membranous nephropathy.