The effect of aminoguanidine in prolonged hemorrhagic shock

Objective To evaluate the effects of am inoguanidine(AG)in prolonged hemorrhagic shock.Methods 28 rabbits subjected to prolonged hemorrhagic shock a nd resuscitation were randomly divided into hemorrhagic shock group(14 rabbits)a n d AG group(14 rabbits,AG was administered as soon as resuscitation was preformde ).The plasma levels of endotoxin,TNF-α,IL-6,IL-8 and NO were detected at pte sh ock,postshock,just after resuscitation and 0.5h,2h,4h after resuscitation. The survival rates of 24h and 48h were observed.Results The plasma levels of endotoxin,TNF-α,IL-6,IL-8 and NO were markedly higher after shock than those of before shock and maintained a t high level.Compared with shock group,lower plasma levels of endotoxin,TNF-α, IL-6,IL-8 and NO,higher survival rate were observed in AG group.Conclusion The endotoxin,TNF-α,IL-6,IL-8 and NO play an i mportant role in the development of hemorrhagic shock.AG used as a selective inh ibitor of the inducible isoform of nitric oxide synthase can improve the outcome of prolonged hemorrhagic shock.