Effects of smecta in prolonged hemorrhagic shock

Objective To evaluate the effects of smecta in prolonged hemorrhagic shock.Methods The modified Wigger's method was used to induce hemorrhagic shock in anesthetized rabbits.Twenty-nine rabbits were randomly divided into hemorrhagic shock group(n=14),smecta group(n=15),with smecta solution being administered via a gavage tube before shock.The plasma levels of endotoxin,tumor necrosis factor α(TNFα),interleukin-6(IL-6) and nitric oxide(NO) were detected at pre-shock and post-shock,immediately after resuscitation and 2h after resuscitation.Blood culture was done at pre-shock,immediately after resuscitation,2h after resuscitation.The survival rates of 24h and 48h were observed.Results The plasma levels of endotoxin,TNFα,IL-6 and NO markedly increased after shock,and were maintained at high level in shock group (P001).Compared with those in shock group,the plasma levels of endotoxin,TNFα,IL-6 and NO,positive incidence of blood culture decreased obviously,and survival rates of 24h and 48h increased significantly in smecta group (P001).Conclusions Oral smecta can not only reduce the endotoxemia during shock,but also decrease the productions of cytokines and NO to improve the outcome of shock.